(1) Mental retardation is obvious as infants grow older.
(2) Marked hypotonia and floppiness.
(3) Joint hyperextension or hyperflexibility.
(4) Tendency to keep mouth open with his tongue protruding, high arched palate, and furrowed tongue.
(5) Eyes slant upwards and outward with internal epicanthal folds.
(6) Flattened nasal bridge and flat facial profile.
(7) Small ears, often incompletely developed, low set.
(8) Single transverse palmar crease-simian crease.
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